IR was defined as the lowest tertile of S-I ( smaller than 1.8 x 10(-4) min(-1)/mu U/ml) and inadequate beta cell compensation was defined as the lowest tertile of DI ( smaller than 900). Data were analyzed using logistic regression models and area under the receiver operating characteristic curve (AUC-ROC). An AUC-ROC bigger than 0.70 was defined as significant discrimination. Results. The mean (+/- SD) age was 38.5 +/- 11.3 years, with BMI of 33.5 +/- 6.7 kg/m(2) and fasting glucose of 86.5 +/- 10.5 mg/dL. The AUC-ROC for the prediction of DI smaller than 900 was 0.74 indicating that a higher TG/HDL-C ratio was associated

with decreased DI. However, the AUC-ROC for prediction of IR or low AIRg ( smaller than 335 mu U/ml) was not significant. Conclusion. This study confirmed that the TG/HDL-C ratio is a poor predictor of IR in AA women. However, we did show an inverse association between the TG/HDL-C Selleck BIX-01294 ratio and beta-cell function, suggesting that this simple tool may effectively identify AA women at risk for DM2. (C) 2015 Elsevier

Inc. All rights reserved.”
“The increased use of metallic nanoparticles (NPs) raises the probability of finding NPs in the environment. A lot of information exists already regarding interactions between plants and metals, but information regarding interactions between metallic NPs and plants, including salt marsh plants, is still lacking. check details This work aimed to study interactions between CuO NPs and the salt marsh plants Halimione portulacoides and Phragmites australis. Selleck Proteasome inhibitor In addition, the potential of these plants for phytoremediation of Cu NPs was evaluated. Plants were exposed for 8 days to sediment elutriate solution doped either with CuO or with ionic Cu. Afterwards, total metal concentrations were determined in plant tissues. Both plants accumulated Cu in their roots, but this accumulation was 4 to 10 times lower when the metal was added in NP form. For P. australis, metal translocation occurred when the metal was added either in ionic or in NP form, but for H. portulacoides

no metal translocation was observed when NPs were added to the medium. Therefore, interactions between plants and NPs differ with the plant species. These facts should be taken in consideration when applying these plants for phytoremediation of contaminated sediments in estuaries, as the environmental management of these very important ecological areas can be affected. (C) 2015 Elsevier Inc. All rights reserved.”
“SNM1B/Apollo is a DNA nuclease that has important functions in telomere maintenance and repair of DNA interstrand crosslinks (ICLs) within the Fanconi anemia (FA) pathway. SNM1B is required for efficient localization of key repair proteins, such as the FA protein, FANCD2, to sites of ICL damage and functions epistatically to FANCD2 in cellular survival to ICLs and homology-directed repair.